N-Methyl-d-aspartic acid or N-Methyl-d-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those for AMPA and kainate). NMDA receptors are particularly important when they become overactive during, for example, withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
Overview: N-Methyl-D-aspartic Acid is one of the 20 common amino acids that are used by the body to construct proteins and is considered to be non-essential since it can be made from oxaloacetate, an intermediate of the tricarboxylic acid cycle.
D-aspartic acid has been shown to have some intriguing effects in several animal species and humans. It has also been shown to enhance gonadotropin releasing hormone release from the hypothalamus as well as growth hormone and luteinizing hormone release from the pituitary gland.
This compound is believed to have natural testosterone boosting properties which leads to increased muscle mass and strength in resistance-trained males when compared to placebo.